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Assembly of RNA Polymerase-II Initiation Complex

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Description

The nuclei of all eukaryotic cells contain three different RNA Polymerases, designated I, II and III. Like the DNA Polymerase that catalyzes DNA replication, RNA Polymerases catalyze the formation of the phosphodiester bonds that link the nucleotides together to form a linear chain. Each eukaryotic RNA Polymerase catalyzes transcription of genes encoding different classes of RNA. RNA Polymerase-II catalyzes transcription of all protein-coding genes; that is, it functions in production of mRNAs. RNA Polymerase-II also produces four snRNAs (small nuclear RNAs) that take part in RNA splicing.The eukaryotic polymerases do not directly recognize their core promoter sequences. The first step in complex formation at a promoter containing a TATA Box is binding of the factor TFIID to a region that [...]

References:

1.TFIIB-related factors in RNA polymerase I transcription.
Knutson BA, Hahn S.
Biochim Biophys Acta. 2013 Mar-Apr;1829(3-4):265-73. doi: 10.1016/j.bbagrm.2012.08.003. Epub 2012 Aug 30. Review.
2.Regulation of expression of human RNA polymerase II-transcribed snRNA genes.
Joana Guiro, Shona Murph.
Open Biol. 2017 Jun; 7(6): 170073. Published online 2017 Jun 14. doi: 10.1098/rsob.170073
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