ProteinLounge
Citations
About Us
Contact Us
Login to Protein Lounge!

CD40 Signaling

This image is a scaled-down version of the actual pathway image. It does not contain any links to the protein information pages.
 

Description

CD40, a TNFR (Tumor Necrosis Factor Receptor) family member, conveys signals regulating diverse cellular responses, ranging from proliferation and differentiation to growth suppression and cell death. First identified and functionally characterized on B-Cells, CD40 is expressed on a plethora of different cell types, including B-Cells, macrophages, dendritic cells, endothelial cells, and fibroblasts, and this widespread expression accounts for the central role of CD40 in the regulation of immune response and host defense (Ref.1). Binding of CD40 with its counter receptor, CD154 (also termed CD40L [CD40 ligand] or GP39), acts on Antigen presenting cells and T-Cells in a bi-directional fashion, mediating both humoral and cellular immune responses (Ref.2).

Unique to particular types of cells, CD40 engagement sets in motion a pattern [...]

References:

1.Tumor progression locus 2 (Tpl2) kinase as a novel therapeutic target for cancer: double-sided effects of Tpl2 on cancer.
Lee HW, Choi HY, Joo KM, Nam DH.
Int J Mol Sci. 2015 Feb 25;16(3):4471-91. doi: 10.3390/ijms16034471. Review.
2.TTRAP, a novel protein that associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor-associated factors (TRAFs), and that inhibits nuclear factor-kappa B activation.
Pype S, Declercq W, Ibrahimi A, Michiels C, Van Rietschoten JG, Dewulf N, de Boer M, Vandenabeele P, Huylebroeck D, Remacle JE.
J Biol Chem. 2000 Jun 16;275(24):18586-93.
You can get all the details on this pathway through subscription