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CTL Mediated Apoptosis

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Description

The CTLs (Cytotoxic T Lymphocytes), also known as killer T-Cells are produced during cell-mediated immunity designed to remove body cells displaying "foreign" epitope, such as virus-infected cells, cells containing intracellular bacteria, and cancer cells with mutant surface proteins. The CTLs are able to kill these cells by inducing a programmed cell death known as apoptosis (Ref.1).

CTLs only respond to foreign antigen when it is presented bound to the MHC-I (Major Histocompatibility Complex Class-I) expressed on the surface of all cells. The CTLs contain granules composed of proteoglycans to which chemokines are complexed. These granules hold pore-forming proteins called perforins and proteolytic enzymes called granzymes in a protected state. When the TCR (T-Cell Receptor Complex) and CD8 of the CTL binds [...]

References:

1.Real-time detection of CTL function reveals distinct patterns of caspase activation mediated by Fas versus granzyme B.
Li J, Figueira SK, Vrazo AC, Binkowski BF, Butler BL, Tabata Y, Filipovich A, Jordan MB, Risma KA.
J Immunol. 2014 Jul 15;193(2):519-28. doi: 10.4049/jimmunol.1301668. Epub 2014 Jun 13.
2.Distinct roles of cytolytic effector molecules for antigen-restricted killing by CTL in vivo.
Janssen EM, Lemmens EE, Gour N, Reboulet RA, Green DR, Schoenberger SP, Pinkoski MJ.
Immunol Cell Biol. 2010 Oct;88(7):761-5. doi: 10.1038/icb.2010.37. Epub 2010 Mar 23.
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