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Cellular Apoptosis Pathway

This image is a scaled-down version of the actual pathway image. It does not contain any links to the protein information pages.


Apoptosis (also called programmed cell death) is a cellular death program that is inherent to all mammalian cells and plays an important role in the regulation of various physiological and pathological conditions. It serves to eliminate any unnecessary or unwanted cells and is a highly regulated process. There are a wide variety of conditions that will result in the apoptotic pathway becoming activated including DNA damage or uncontrolled proliferation. The apoptotic pathway is activated by both intracellular and extracellular signals. The central apoptotic machinery can be divided into two major signaling pathways, comprising the death receptor (extrinsic) and the mitochondrial (intrinsic) pathway. Both pathways eventually fuel into a common effector phase that is characterized by the activation of caspases (Ref.1& [...]


1.Apoptosis: A Target for Anticancer Therapy.
Pfeffer CM, Singh ATK.
Int J Mol Sci. 2018 Feb 2;19(2). pii: E448. doi: 10.3390/ijms19020448. Review.
2.Targeting apoptosis signaling pathways for anticancer therapy.
Fulda S.
Front Oncol. 2011 Aug 27;1:23. doi: 10.3389/fonc.2011.00023. eCollection 2011.
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