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Checkpoint Comparative Pathways

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Description

Cell cycle checkpoints are surveillance mechanisms that monitor the order, integrity, and fidelity of the major events of the cell cycle. These include growth to the appropriate cell size, the replication and integrity of the chromosomes, and their accurate segregation at mitosis. Many of these mechanisms are ancient in origin and highly conserved, and hence have been heavily informed by studies in simple organisms such as the yeasts. Others have evolved in higher organisms, and control alternative cell fates with significant impact on tumor suppression.Recent work on the mechanisms of DNA damage and replication cell cycle checkpoints has revealed great similarity between the checkpoint pathways of organisms as diverse as yeasts, flies, humans and mouse. However, there are differences in [...]

References:

1.Cell cycle regulation by checkpoints.
Barnum KJ, O'Connell MJ.
Methods Mol Biol. 2014;1170:29-40. doi: 10.1007/978-1-4939-0888-2_2.
2.The phosphorylation network for efficient activation of the DNA replication checkpoint in fission yeast.
Yue M, Singh A, Wang Z, Xu YJ.
J Biol Chem. 2011 Jul 1;286(26):22864-74. doi: 10.1074/jbc.M111.236687. Epub 2011 May 11.
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