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Cytokine Network

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Description

The immune system recognizes the presence of pathogens by several proteins that bind to molecules secreted by the pathogen or carried on their surface. The cells responsible for these immune responses include the B-Cells, T-Cells, macrophages, neutrophils, basophils, eosinophils, endothelial cells, or mast cells (Ref.1). These cells have distinct roles in the immune system, and communicate with other immune cells by cytokines, which control proliferation, differentiation and function of cells of the immune system. Cytokines provide cells with the ability to communicate with one another and orchestrate complex multicellular behaviour. Cytokines play an important role in normal homeostatic tissue function and dysregulation of these cytokine networks is associated with pathological conditions (Ref.2).

Cytokines have been classified on the basis of their [...]

References:

1.Pathways for cytokine secretion.
Stanley AC, Lacy P.
Physiology (Bethesda). 2010 Aug;25(4):218-29. doi: 10.1152/physiol.00017.2010. Review.
2.Cytokine networks in neuroinflammation.
Becher B, Spath S, Goverman J.
Nat Rev Immunol. 2017 Jan;17(1):49-59. doi: 10.1038/nri.2016.123. Epub 2016 Dec 5. Review.
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