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D-Alanine Metabolism in O. iheyensis

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Oceanobacillus iheyensis is an alkaliphilic and extremely halotolerant Bacillus-related species isolated from deep-sea sediment. It is also known as small ocean bacillus pertaining to the Iheya Ridge from where it was isolated. O. iheyensis grows at depths of up to 3,000 m. The bacteria thrive under high hydrostatic pressure and grow optimally at about 30 degrees Celsius (Ref. 1, 2 & 3).

The cell wall of this bacterium is a unique biopolymer, containing both D- and L-Amino acids. The terminal peptide is D-Alanine although other amino acids are present as D-isomers and this is the only known biological molecule that contains D-Amino acids, which are responsible for the building of peptidoglycan. A key step in peptidoglycan layer assembly and deposition is [...]


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