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D-Alanine Metabolism in S. mutans

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Based on differences in their compositions and the linkages of cell wall polysaccharides, Streptococci are classified into eight serotypes as follows; Streptococcus mutans (Serotypes c, e, and f), Streptococcus sobrinus (Serotypes d and g), Streptococcus cricetus (Serotype a), Streptococcus rattus (Serotype b), Streptococcus ferus (Serotype c), Streptococcus macacae (Serotype c), and Streptococcus downei (Serotype h). Among these, S. mutans is known to be a major causative bacterium of dental caries in humans and is occasionally isolated from the blood of patients with infective endocarditis (Ref.1). The cell wall of this bacterium is a peptidoglycan macromolecule with attached accessory molecules such as TAs (Teichoic Acids), Teichuronic Acids, LTA (Lipoteichoic Acids) polyphosphates and carbohydrates (Ref.1, 2 & 5). The LTA of many [...]


1.Defects in D-alanyl-lipoteichoic acid synthesis in Streptococcus mutans results in acid sensitivity.
Boyd DA, Cvitkovitch DG, Bleiweis AS, Kiriukhin MY, Debabov DV, Neuhaus FC, Hamilton IR.
J Bacteriol. 2000 Nov; 182(21):6055-65.
2.D-alanylation of lipoteichoic acid: role of the D-alanyl carrier protein in acylation.
Kiriukhin MY, Neuhaus FC.
J Bacteriol. 2001 Mar; 183(6):2051-8.
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