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EIF2 Pathway

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Protein synthesis in eukaryotic organisms is a complex process that requires cooperation among a large number of polypeptides including ribosomal proteins, modification of enzymes, and ribosome-associated translation factors. The initiation phase of protein synthesis, during which ribosomes select mRNAs to be translated and identify the translational start site, requires a set of eIFs (eukaryotic Translation Initiation Factors), many of which are comprised of multiple polypeptide subunits. EIF2 (Eukaryotic Initiation Factor-2) is a GTP (Guanosine Triphosphate)-binding protein that escorts the initiation-specific form of Met-tRNA (Met-tRNAi) onto the ribosome. It is composed of 3 non-identical subunits, alpha (36 kD), beta (38 kD), and gamma (52 kD). cDNAs for each of the subunits have been cloned and sequenced from a variety of species, [...]


1.The mechanism of eukaryotic translation initiation and principles of its regulation.
Jackson RJ, Hellen CU, Pestova TV.
Nat Rev Mol Cell Biol. 2010 Feb;11(2):113-27. doi: 10.1038/nrm2838. Review.
2.eIF2 interactions with initiator tRNA and eIF2B are regulated by post-translational modifications and conformational dynamics.
Beilsten-Edmands V, Gordiyenko Y, Kung JC, Mohammed S, Schmidt C, Robinson CV.
Cell Discov. 2015 Aug 11;1:15020. doi: 10.1038/celldisc.2015.20. eCollection 2015.
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