About Us
Contact Us
Login to Protein Lounge!

Erythropoietin Pathway

This image is a scaled-down version of the actual pathway image. It does not contain any links to the protein information pages.


Erythropoiesis is a major pathway for Erythrocyte production, by which pluripotent Hematopoietic Stem Cells give rise to mature end stage cells via a series of differentiations. Epo (Erythropoietin), a glycoprotein hormone and a multifunctional Hematopoietic Cytokine ligand, is the master regulator of Erythropoiesis. As a major function, it monitors the safe passage of the committed Erythroid progenitor cells through several physiological and developmental stages by stimulating Growth, preventing Apoptosis, and promoting terminal differentiation. In addition to its immense survival strategies, Epo initiates Hemoglobin synthesis and is an essential viability and Growth factor in the maintenance of a steady physiological level of circulating Erythrocyte mass which ensure adequate tissue Oxygen levels and maintain an appropriate Oxygen supply throughout the body (Ref.1 [...]


1.Erythropoiesis: development and differentiation.
Dzierzak E, Philipsen S.
Cold Spring Harb Perspect Med. 2013 Apr 1;3(4):a011601. doi: 10.1101/cshperspect.a011601. Review.
2.The effect of erythropoietin on normal and neoplastic cells.
Elliott S, Sinclair AM.
Biologics. 2012;6:163-89. doi: 10.2147/BTT.S32281. Epub 2012 Jun 27.
You can get all the details on this pathway through subscription