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Factors Promoting Cardiogenesis in Vertebrates

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Heart is the first organ to form and function in the Embryo, and all subsequent events in the life of the organism depend on the Heart s ability to match its output with the organism s demands for Oxygen and nutrients. Abnormalities in Heart formation, the most common form of Human birth defects, affect nearly 1% of newborns, and their frequency in spontaneously aborted pregnancies is estimated to be tenfold higher. Heart development is an elaborate process requiring Cell specification, Cell differentiation, Cell migration, morphogenesis, and interactions among cells from several embryonic origins. The Heart is formed through multiple developmental steps, which include the determination of the Cardiac field in the mesoderm, differentiation of Cardiac precursor cells, and maturation of the Heart. [...]


1.Development of the building plan of the heart.
Moorman AF, Soufan AT, Hagoort J, de Boer PA, Christoffels VM.
Ann N Y Acad Sci. 2004 May;1015:171-81.
2.What does it take to make a heart?
Pandur P.
Biol Cell. 2005 Mar;97(3):197-210.
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