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HSV1 Latent Infection

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Herpesviridae is a large family of viruses including several members that are pathogenic to humans, causing a variety of disorders ranging from cold sores and chicken pox to less frequent conditions such as blindness and cancers. HSV1 (Herpes Simplex Virus Type-1), the prototypical member of this family, is a large DNA-containing neurotropic virus endemic in all human populations. Following an initial infection in epithelial cells, the virus spreads to neurons of sensory ganglia, where it becomes latent. The virus emerges sporadically from latency, causing recurrent mucocutaneous lesions. Reactivation of the latent genomes upon stress can lead to re-infection of the epithelial tissue by anterograde spread or in immunosuppressed patients to life-threatening diseases by further retrograde spread (Herpes encephalitis). In rare [...]


1.Herpes simplex virus glycoprotein D bound to the human receptor HveA.
Carfi A, Willis SH, Whitbeck JC, Krummenacher C, Cohen GH, Eisenberg RJ, Wiley DC.
Mol. Cell. 2001 Jul; 8(1):169-79.
2.Herpes virus entry: an update.
Spear PG, Longnecker R.
J. Virol. 2003 Oct; 77(19):10179-85.
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