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Transcriptional Regulatory Network in Embryonic Stem Cell

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Stem Cells are undifferentiated cells that can give rise to several lineages of differentiated cell types. They are the founder cells for every organ, tissue and cell in the body. Stem cells are characterized by the ability to self-renew and maintain Pluripotency. These features allow Stem Cells to fulfill their multiple functions, namely to provide enough cells during organogenesis, to control tissue homeostasis and, in addition, to ensure regeneration and repair. ESCs (Embryonic Stem Cells) are derived from the ICM (Inner Cell Mass) of the developing Blastocysts, multicellular structures originating from four (Human) to five (Mouse) cleavages of fertilized oocytes. In Human, the fertilization of an Egg by a Sperm generates a Zygote that thirty hours later begins to divide. [...]


1.Concise review: pursuing self-renewal and pluripotency with the stem cell factor Nanog.
Saunders A, Faiola F, Wang J.
Stem Cells. 2013 Jul;31(7):1227-36. doi: 10.1002/stem.1384. Review.
2.Totipotency and lineage segregation in the human embryo.
De Paepe C, Krivega M, Cauffman G, Geens M, Van de Velde H.
Mol Hum Reprod. 2014 Jul;20(7):599-618. doi: 10.1093/molehr/gau027. Epub 2014 Apr 3. Review.
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