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Tumoricidal Effects of Hepatic NK Cells

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The liver is a major site for the formation and metastasis of Tumors. Malignant Liver Tumors fall into two types: Primary and Metastatic. While Primary Liver tumors such as HCC (Hepatocellular Carcinoma) originate in the liver itself, Metastatic or Secondary Liver Tumors commpnly known as “Liver Metastases” are cancerous tumors that originate at sites remote from the liver and spread to the liver via the bloodstream. As filtration of blood is one of the main functions of Liver, cancer cells from other parts of the body have easy access to the Liver. It provides a fertile platform in which Metastases can establish, not only because of its rich, dual blood supply but also because of humoral factors that promote cell [...]


1.Application of tissue-specific NK and NKT cell activity for tumor immunotherapy.
Subleski JJ, Wiltrout RH, Weiss JM.
J Autoimmun. 2009 Nov-Dec;33(3-4):275-81.
2.Regulation of NK cell repertoire and function in the liver.
Krueger PD, Lassen MG, Qiao H, Hahn YS.
Crit Rev Immunol. 2011;31(1):43-52.
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