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Ubiquitin-Proteasome Dependent Proteolysis

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Description

The Proper functioning of a cell requires careful control of the levels of important structural proteins, enzymes, and regulatory proteins. Protein molecules are continuously synthesised and degraded in all living organisms. The concentration of individual cellular proteins is determined by a balance between the rates of synthesis and degradation, which in turn are controlled by a series of regulated biochemical mechanisms. Differences in the rates of protein synthesis and breakdown result in cellular and tissue atrophy (loss of proteins from cells) and hypertrophy (increase in protein content of cells). Precise control of protein turnover is, therefore, essential to cellular survival. The only way that cells can reduce the excessive level of a particular protein is by proteolytic degradation. Although protein [...]

References:

1.Altered ubiquitin causes perturbed calcium homeostasis, hyperactivation of calpain, dysregulated differentiation, and cataract.
Liu K, Lyu L, Chin D, Gao J, Sun X, Shang F, Caceres A, Chang ML, Rowan S, Peng J, Mathias R, Kasahara H, Jiang S, Taylor A.
Proc Natl Acad Sci U S A. 2015 Jan 27;112(4):1071-6. doi: 10.1073/pnas.1404059112. Epub 2015 Jan 12. Erratum in: Proc Natl Acad Sci U S A. 2015 Feb 17;112(7):E817. Jian, Shuhong [corrected to Jiang, Shuhong].
2.Ubiquitin-Like Proteasome System Represents a Eukaryotic-Like Pathway for Targeted Proteolysis in Archaea.
Fu X, Liu R, Sanchez I, Silva-Sanchez C, Hepowit NL, Cao S, Chen S, Maupin-Furlow J.
MBio. 2016 May 17;7(3). pii: e00379-16. doi: 10.1128/mBio.00379-16. Erratum in: MBio. 2016;7(4). pii: e01192-16. doi: 10.1128/mBio.01192-16.
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