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Cell Biology News
Fri, 19 Apr 2019 16:55:25 EDT
A universal framework combining genome annotation and undergraduate education
Scientists and educators have developed a framework for using new genome sequences as a training resource for undergraduates interested in learning genome annotation. This strategy will both make the process of determining gene functions more efficient and help train the next generation of scientists in bioinformatics.
Fri, 19 Apr 2019 10:37:08 EDT
Warming: Plants are also stressed out
What will a three-degree-warmer world look like? When experiencing stress or damage from various sources, plants use chloroplast-to-nucleus communication to regulate gene expression and help them cope. Now, researchers have found that GUN1 -- a gene that integrates numerous chloroplast-to-nucleus retrograde signaling pathways -- also plays an important role in how proteins are made in damaged chloroplasts, which provides a new insight into how plants respond to stress.
Fri, 19 Apr 2019 10:36:57 EDT
New method to detect off-target effects of CRISPR
Since the CRISPR genome editing technology was invented in 2012, it has shown great promise to treat a number of intractable diseases. However, scientists have struggled to identify potential off-target effects in therapeutically relevant cell types, which remains the main barrier to moving therapies to the clinic. Now, a group of scientists have developed a reliable method to do just that.
Fri, 19 Apr 2019 09:39:54 EDT
On-chip drug screening for identifying antibiotic interactions in eight hours
A research team developed a microfluidic-based drug screening chip that identifies synergistic interactions between two antibiotics in eight hours. This chip can be a cell-based drug screening platform for exploring critical pharmacological patterns of antibiotic interactions, along with potential applications in screening other cell-type agents and guidance for clinical therapies.
Thu, 18 Apr 2019 14:52:35 EDT
How the hepatitis B virus establishes persistent infection
New research sheds light on how a hepatitis B viral protein stimulates the expansion of immune cells that impair antiviral responses. The findings potentially explain how the hepatitis B virus (HBV) establishes and maintains chronic infection, and could lead to the development of novel therapeutic strategies.
Thu, 18 Apr 2019 14:17:19 EDT
Flies smell through a Gore-Tex system
Scientists have gained important insights into how the nanopores that allow the fruit fly to detect chemicals in the air, and has identified the gene responsible for their development.
Thu, 18 Apr 2019 14:16:19 EDT
Certain strains of bacteria associated with diabetic wounds that do not heal
Whether a wound -- such as a diabetic foot ulcer -- heals or progresses to a worse outcome, including infection or even amputation, may depend on the microbiome within that wound.
Thu, 18 Apr 2019 14:16:11 EDT
New immune pathway involved in resistance to parasite worms found in undercooked pork
Scientists have discovered that immune responses originally found to prevent fungal infections are also important in eliminating Trichinella spiralis, a round worm and the causative agent of Trichinosis. People acquire trichinellosis by consuming raw or undercooked meat infected with the Trichinella parasite, particularly wild game meat or pork.
Thu, 18 Apr 2019 14:16:04 EDT
Infection biology: Gut microbe helps thwart Salmonella
Researchers have identified a bacterial species in the gut microbiome of the mouse which protects against infection by human-pathogenic Salmonella.
Thu, 18 Apr 2019 14:15:54 EDT
Bioengineers program cells as digital signal processors
Synthetic biologists have added high-precision analog-to-digital signal processing to the genetic circuitry of living cells. The research dramatically expands the chemical, physical and environmental cues engineers can use to prompt programmed responses from engineered organisms.
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