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Health & Medicine News
Fri, 19 Apr 2019 10:37:13 EDT
Discovery may help explain why women get autoimmune diseases far more often than men
New evidence points to a key role for a molecular switch called VGLL3 in autoimmune diseases, and the major gap in incidence between women and men. Building on past research showing that women have more VGLL3 in their skin cells than men, a team studied it further in mice. They show that having too much VGLL3 in skin cells pushes the immune system into overdrive, leading to an autoimmune response and symptoms similar to lupus.
Fri, 19 Apr 2019 10:36:57 EDT
New method to detect off-target effects of CRISPR
Since the CRISPR genome editing technology was invented in 2012, it has shown great promise to treat a number of intractable diseases. However, scientists have struggled to identify potential off-target effects in therapeutically relevant cell types, which remains the main barrier to moving therapies to the clinic. Now, a group of scientists have developed a reliable method to do just that.
Fri, 19 Apr 2019 09:40:26 EDT
Marijuana users weigh less, defying the munchies
New evidence suggests that those who smoke cannabis, or marijuana, weigh less compared to adults who don't. The findings are contrary to the belief that marijuana users who have a serious case of the munchies will ultimately gain more weight.
Fri, 19 Apr 2019 09:39:54 EDT
On-chip drug screening for identifying antibiotic interactions in eight hours
A research team developed a microfluidic-based drug screening chip that identifies synergistic interactions between two antibiotics in eight hours. This chip can be a cell-based drug screening platform for exploring critical pharmacological patterns of antibiotic interactions, along with potential applications in screening other cell-type agents and guidance for clinical therapies.
Thu, 18 Apr 2019 20:13:33 EDT
Important insight on the brain-body connection
A study reveals that neurons in the motor cortex exhibit an unexpected division of labor, a finding that could help scientists understand how the brain controls the body and provide insight on certain neurological disorders.
Thu, 18 Apr 2019 20:13:29 EDT
Investigators incorporate randomized trial within dialysis care delivery
The Time to Reduce Mortality in ESRD (TiME) trial was a large pragmatic trial demonstration project designed to determine the benefits of hemodialysis sessions that are longer than many patients currently receive. The trial was conducted through a partnership between academic investigators and 2 large dialysis provider organizations using a highly centralized implementation approach. Although the trial accomplished most of its demonstration project objectives, uptake of the intervention was insufficient to determine whether longer sessions improve outcomes.
Thu, 18 Apr 2019 20:13:25 EDT
BRB-seq: The quick and cheaper future of RNA sequencing
Bioengineers have developed a new method for Bulk RNA Sequencing that combines the multiplexing-driven cost-effectiveness of a single-cell RNA-seq workflow with the performance of a bulk RNA-seq procedure.
Thu, 18 Apr 2019 16:43:40 EDT
Behavioral disorders in kids with autism linked to reduced brain connectivity
More than a quarter of children with autism spectrum disorder are also diagnosed with disruptive behavior disorders. Now researchers have identified a possible biological cause: a key mechanism that regulates emotion functions differently in the brains of the children who exhibit disruptive behavior.
Thu, 18 Apr 2019 14:52:35 EDT
How the hepatitis B virus establishes persistent infection
New research sheds light on how a hepatitis B viral protein stimulates the expansion of immune cells that impair antiviral responses. The findings potentially explain how the hepatitis B virus (HBV) establishes and maintains chronic infection, and could lead to the development of novel therapeutic strategies.
Thu, 18 Apr 2019 14:17:22 EDT
Does time of day affect the body's response to exercise?
New research confirms that the circadian clock is an important factor in how the body responds to physical exertion. Based on this work alone, it's too early to say when the best time is for you to go for a jog. But at least in the lab, exercise in the evening seems to be more productive, although human lifestyles are much more complicated.
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