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Molecular Biology News
Mon, 12 Nov 2018 13:16:35 EST
Pulling the genome apart: Chromosome segregation during mitosis explained
Researchers shed light on the protein complexes and processes that enable microtubules to bind to the centromeres of chromosomes and redistribute them to the daughter cells during mitosis. Via experiments including partial protein deletion, chimeric protein production, and measurement of microtubule pulling force, the team showed that interaction of the Ndc80 complex with the CENP-T pathway of kinetochores, not the CENP-C one, is essential for successful cell division.
Mon, 12 Nov 2018 09:59:34 EST
Stripping the linchpins from the life-making machine reaffirms its seminal evolution
This experiment had a good chance of crashing. Instead, it delivered whopping evidence to corroborate the earliest evolution of the translational system, the mechanisms which make life out of our genes. The study swapped out all its magnesium, tabula rasa, and showed that the system, centering on the ribosome, would have thrived basically as it is today 4 billion years ago at the earliest foundations of life on Earth.
Mon, 12 Nov 2018 08:24:23 EST
How your muscles form
An international team of researchers discovers two proteins essential to the development of skeletal muscle.
Fri, 09 Nov 2018 10:15:14 EST
Scientists simplify and accelerate directed evolution bioengineering method
Researchers reported that they have accelerated and simplified directed evolution by having live cells do most of the heavy lifting. By inserting a specially engineered DNA replication system into yeast, the scientists were able to coax selected genes to rapidly and stably mutate and evolve as the host yeast cells reproduced.
Fri, 09 Nov 2018 10:14:14 EST
Fully identified: The pathway of protons
The question how certain algal enzymes accomplish the high proton transfer rate for hydrogen production had in the past been subject to speculation. Researchers traced the pathway of protons all the way into the active center of [FeFe]-hydrogenases. Their findings might enable scientists to create stable chemical reproductions of such efficient, yet fragile biocatalysts.
Thu, 08 Nov 2018 14:24:54 EST
Embryos 'remember' the chemicals that they encounter
A new study shows that embryonic cells retain a memory of the chemical signals to which they are exposed. Without these memories, cells fail organize into distinct tissue types.
Thu, 08 Nov 2018 14:23:56 EST
Can't sleep? Fruit flies and energy drinks offer new clues
Like humans, fruit flies are active during the day, sleep at night and have similar sleep characteristics. A study has discovered a new gene and uncovered a mechanism that modulates sleep by controlling the movement of taurine -- a common ingredient found in many energy drinks -- into neuron cells of the fly brain. Taurine also is abundant in the human brain and is consistently elevated in blood and urine of sleep-deprived people.
Thu, 08 Nov 2018 14:23:01 EST
We now know how RNA molecules are organized in cells
Researchers have for the first time visualized how RNA molecules are organized in cells.
Thu, 08 Nov 2018 14:22:19 EST
Self-assembling protein filaments designed and built from scratch
For the first time, scientists have created, from scratch, self-assembling protein filaments built from identical protein subunits that snap together spontaneously to form long, helical, thread-like configurations. Protein filaments are essential components of several structural and moving parts in living cells, as well as many body tissues. Being able to design and build protein filaments could allow for engineering novel materials for nano-electronics or scaffolds for new diagnostic tests.
Thu, 08 Nov 2018 13:05:03 EST
Toxin complex of the plague bacterium and other germs decoded
Researchers decode the toxin complex of the plague bacterium and other germs.
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