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Molecular Biology News
Fri, 19 Apr 2019 10:37:08 EDT
Warming: Plants are also stressed out
What will a three-degree-warmer world look like? When experiencing stress or damage from various sources, plants use chloroplast-to-nucleus communication to regulate gene expression and help them cope. Now, researchers have found that GUN1 -- a gene that integrates numerous chloroplast-to-nucleus retrograde signaling pathways -- also plays an important role in how proteins are made in damaged chloroplasts, which provides a new insight into how plants respond to stress.
Fri, 19 Apr 2019 10:36:57 EDT
New method to detect off-target effects of CRISPR
Since the CRISPR genome editing technology was invented in 2012, it has shown great promise to treat a number of intractable diseases. However, scientists have struggled to identify potential off-target effects in therapeutically relevant cell types, which remains the main barrier to moving therapies to the clinic. Now, a group of scientists have developed a reliable method to do just that.
Thu, 18 Apr 2019 14:52:35 EDT
How the hepatitis B virus establishes persistent infection
New research sheds light on how a hepatitis B viral protein stimulates the expansion of immune cells that impair antiviral responses. The findings potentially explain how the hepatitis B virus (HBV) establishes and maintains chronic infection, and could lead to the development of novel therapeutic strategies.
Thu, 18 Apr 2019 14:17:19 EDT
Flies smell through a Gore-Tex system
Scientists have gained important insights into how the nanopores that allow the fruit fly to detect chemicals in the air, and has identified the gene responsible for their development.
Thu, 18 Apr 2019 14:15:54 EDT
Bioengineers program cells as digital signal processors
Synthetic biologists have added high-precision analog-to-digital signal processing to the genetic circuitry of living cells. The research dramatically expands the chemical, physical and environmental cues engineers can use to prompt programmed responses from engineered organisms.
Thu, 18 Apr 2019 13:12:51 EDT
Cell-killing proteins suppress listeria without killing cells
New research shows that key proteins known for their ability to prevent viral infections by inducing cell death can also block certain bacterial infections without triggering the death of the host cells.
Wed, 17 Apr 2019 17:10:25 EDT
Researchers use gene editing with CRISPR to treat lethal lung diseases before birth
Using CRISPR gene editing, researchers have thwarted a lethal lung disease in an animal model in which a harmful mutation causes death within hours after birth. This proof-of-concept study showed that in utero editing could be a promising new approach for treating lung diseases before birth.
Wed, 17 Apr 2019 13:27:50 EDT
Diet high in leucine may fuel breast cancer's drug resistance
Researchers have discovered an unexpected relationship between levels of the amino acid leucine (found in beef, chicken, pork and fish and other foods) and the development of tamoxifen resistance in estrogen-receptor positive breast cancer. These findings reveal a potential new strategy for overcoming resistance to endocrine drugs in ER positive breast cancer patients.
Wed, 17 Apr 2019 13:00:02 EDT
Making a fast ion transporter
An international team of researchers reveals an ion transport mechanism of sodium/proton antiporter by simulating its motion. Based on the simulations, they now design a faster transporter by making mutation on ''gate'' of the transporter.
Wed, 17 Apr 2019 11:14:32 EDT
New deep-learning approach predicts protein structure from amino acid sequence
A scientist has used a form of artificial intelligence known as deep learning to predict the 3D structure of effectively any protein based on its amino acid sequence. This new approach for computationally determining protein structure achieves accuracy comparable to current state-of-the-art methods but at speeds upward of a million times faster.
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