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14-3-3 Induced Intracellular Signaling

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The 14-3-3 family of proteins consists of molecular adaptors that recognize phosphorylated proteins (e.g. kinases, transcription factors and receptors). They are able to coordinate almost limitless combinations of protein complexes, which accounts for their functional diversity (Ref.1). This plethora of interacting proteins allows 14-3-3 to play important roles in a wide range of vital regulatory processes, such as neuronal development, mitogenic signal transduction, apoptotic cell death, cell cycle control, cell growth control, and viral and bacterial pathogenesis. More than 50 signaling proteins have been reported as 14-3-3 ligands (Ref.1). Seven mammalian isoforms of 14-3-3 proteins (α/β, ɛ, η, γ, τ/θ, δ/ζ, σ) have been identified so far. A common outcome of 14-3-3 protein binding is translocation of target proteins into [...]


1.14-3-3 proteins are essential signalling hubs for beta cell survival.
Lim GE, Piske M, Johnson JD.
Diabetologia. 2013 Apr;56(4):825-37. doi: 10.1007/s00125-012-2820-x. Epub 2013 Jan 26.
2.Regulation of RAF activity by 14-3-3 proteins: RAF kinases associate functionally with both homo- and heterodimeric forms of 14-3-3 proteins.
Fischer A, Baljuls A, Reinders J, Nekhoroshkova E, Sibilski C, Metz R, Albert S, Rajalingam K, Hekman M, Rapp UR.
J Biol Chem. 2009 Jan 30;284(5):3183-94. doi: 10.1074/jbc.M804795200. Epub 2008 Dec 2.
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