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14-3-3 in Apoptosis

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14-3-3 proteins are abundantly expressed adaptor proteins that interact with a vast number of binding partners to regulate their cellular localization and function. They regulate substrate function in a number of ways including protection from dephosphorylation, regulation of enzyme activity, formation of ternary complexes and sequestration. They are key regulators of major cellular processes such as proliferation, differentiation, senescence and apoptosis (Ref.1 and 2). Apoptosis is a physiological process of cell death that plays a critical role in normal development as well as in the pathophysiology of a variety of diseases. The fundamental cellular mechanism behind apoptosis is due to a balance between anti-apoptotic and pro-apoptotic factors, which may be shifted by extracellular signals. 14-3-3 proteins play an important suppressing [...]


1.Neuroprotective function of 14-3-3 proteins in neurodegeneration.
Shimada T, Fournier AE, Yamagata K.
Biomed Res Int. 2013;2013:564534. doi: 10.1155/2013/564534. Epub 2013 Dec 2. Review.
2.Cellular functions of 14-3-3 zeta in apoptosis and cell adhesion emphasize its oncogenic character.
Niemantsverdriet M, Wagner K, Visser M, Backendorf C.
Oncogene. 2008 Feb 21;27(9):1315-9. Epub 2007 Aug 20.
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