About Us
Contact Us
Login to Protein Lounge!

4-1BB Pathway

This image is a scaled-down version of the actual pathway image. It does not contain any links to the protein information pages.


4-1BB is an inducible T cell surface receptor belonging to the tumor necrosis factor receptor super family. It presents on the surfaces of activated CD4+ and CD8+ T cells, monocytes and B lymphocytes. 4-1BB signaling is activated by binding to its high-affinity ligand 4-1BBL which is expressed on the surface of antigen-presenting cell. 4-1BB signaling promotes cell growth, T cell differentiation and survival of immune cells (Ref.1&2).

4-1BB mediates its action via association with TRAF1, TRAF2 and TRAF3. 4-1BB binding to TRAF2 and TRAF3/ cIAP complex leads to activation of the NIK. NIK activates NF-kB via the IKK-alpha/ NFKBIA pathway (Ref.2, 3, 4&5).NF-kB induces transcription of Bcl-XL, Bcl-2 and BFL1, and thus promotes survival of immune cells (Ref.6, 7&8). [...]


1.Import of human and Thermoplasma 20S proteasomes into nuclei of HeLa cells requires functional NLS sequences.
Wang HR, Kania M, Baumeister W, Nederlof PM
Eur J Cell Biol. 1997 Jun;73(2):105-13.
2.Role of 4-1BB in immune responses.
Vinay DS, Kwon BS
Semin Immunol. 1998 Dec; 10(6):481-9.
You can get all the details on this pathway through subscription