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AHR Pathway

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AHR is a cytosolic receptor for low molecular weight molecules, binding and becoming activated by sterically planar ligands approximately three benzene rings in size. It is maximally expressed in interface tissues including the liver, lungs, skin and gastrointestinal tract [Ref.1]. It is recognized as the culprit for most toxic responses observed after exposure to PAH (Polycyclic Aromatic Hydrocarbons), Dioxins (e.g. TCDD (2, 3, 7, 8-tetrachlorodibenzo-p-dioxin)), and PCBs(Polychlorinated Biphenyls),3MC,β-NF and B[a]P. It is also activated by FICZ, which is formed upon absorption of UVB by TRP (tryptophan) and results in dissociation of PP60 from the complex [2&3]. AHR can affect cellular signaling through interactions with various Regulatory and Signaling proteins, including PAS heterodimerization partners ARNT (Aryl Hydrocarbon Receptor Nuclear Translocator), Chaperone [...]


1.The aryl hydrocarbon receptor: a review of its role in the physiology and pathology of the integument and its relationship to the tryptophan metabolism.
Noakes R.
Int J Tryptophan Res. 2015 Feb 10; 8:7-18. doi: 10.4137/IJTR.S19985. eCollection 2015. Review.
2.Ah receptor: dioxin-mediated toxic responses as hints to deregulated physiologic functions.
Bock KW, Köhle C.
Biochem Pharmacol. 2006 Aug 14; 72(4):393-404. Epub 2006 Mar 20. Review.
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