About Us
Contact Us
Login to Protein Lounge!

Activation of cAMP-Dependent PKA

This image is a scaled-down version of the actual pathway image. It does not contain any links to the protein information pages.


cAMP (Cyclic 3 , 5 -Adenosine Monophosphate)-dependent Protein Kinase, commonly known as PKA (Protein Kinase-A), is a second messenger-dependent enzyme that has been implicated in a wide range of cellular processes, including transcription, metabolism, cell cycle progression and apoptosis. Known modulators of PKA activity include factors that either activate or inhibit AC (Adenylate Cyclase), resulting in an increase or decrease in cAMP levels. The enzyme occurs naturally as a four-membered structure with two regulatory (R) and two catalytic (C) subunits. Four genes encode the R subunits (RI-Alpha, RI-Beta, RII-Alpha and RII-Beta), and three encode the C subunits (C-Alpha, C-Beta and C-Gamma). Although there are major differences in the tissue distribution, biochemical and physical properties of the R subunit isoforms, differences between the [...]


1.Targeting protein kinase A in cancer therapy: an update.
Sapio L, Di Maiolo F, Illiano M, Esposito A, Chiosi E, Spina A, Naviglio S.
EXCLI J. 2014 Aug 18;13:843-55. eCollection 2014. Review.
2.Evolutionary paths of the cAMP-dependent protein kinase (PKA) catalytic subunits.
Søberg K, Jahnsen T, Rognes T, Skålhegg BS, Laerdahl JK.
PLoS One. 2013 Apr 12;8(4):e60935. doi: 10.1371/journal.pone.0060935. Print 2013.
You can get all the details on this pathway through subscription