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Alzheimer’s Disease Pathway

This image is a scaled-down version of the actual pathway image. It does not contain any links to the protein information pages.


AD (Alzheimer’s Disease) is a neurodegenerative disorder leading to amnesia, cognitive impairment, and senile dementia. Two types of lesions characterize the disease: SPs (Amyloid or Senile Plaques) resulting from the extracellular aggregation of ABeta (Amyloid Beta) peptide, which is derived from a ubiquitous type I transmembrane protein named APP (Amyloid Precursor Protein), and NFTs (Neuro-Fibrillary Tangles) composed of intraneuronal bundles of PHF (Paired Helical Filaments). PHF result from the aggregation of pathologic Tau proteins, named PHF-Tau1. Both lesions extend progressively to neocortical brain areas during the course of Alzheimer Disease. The link between Amyloid deposits and NFTs is not yet clear. The vast majority of cases of Alzheimer Disease are sporadic with no clear pattern of inheritance and a late [...]


1.Alzheimer's disease: genes, proteins, and therapy.
Selkoe DJ.
Physiol Rev. 2001 Apr;81(2):741-66.
2.Transcriptional regulation of BACE1, the beta-amyloid precursor protein beta-secretase, by Sp1.
Christensen MA, Zhou W, Qing H, Lehman A, Philipsen S, Song W.
Mol Cell Biol. 2004 Jan;24(2):865-74.
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