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Antigen Processing and Presentation by MHCs

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In order to initiate a specific immune response to an infectious agent, the immune system must be able to wade through the sea of molecules that are associated with pathogenic invasion and isolate particular protein products that will sharpen the efforts of host defense. Implicit to this model of counteraction is the processing of an immunogenic peptide epitope (Antigen Processing) and its presentation on the surface of a team of cells, referred to as APCs (Antigen Presenting Cells) (Antigen Presentation). The result of these actions is the induction of a T-Cell response that recruits and engages the other molecular participants of the immune response. Antigen processing and presentation refer to the processes that occur within a cell that result in [...]


1.Endogenous viral antigen processing generates peptide-specific MHC class I cell-surface clusters.
Lu X, Gibbs JS, Hickman HD, David A, Dolan BP, Jin Y, Kranz DM, Bennink JR, Yewdell JW, Varma R.
Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):15407-12. Epub 2012 Sep 4.
2.Prediction of peptides binding to MHC class I and II alleles by temporal motif mining.
Meydan C, Otu HH, Sezerman OU.
BMC Bioinformatics. 2013;14 Suppl 2:S13. doi: 10.1186/1471-2105-14-S2-S13. Epub 2013 Jan 21.
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