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Antiproliferative Role of SSTR2

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Somatostatin is a widely distributed peptide hormone that plays an important inhibitory role in several biological processes, including neurotransmission, exocrine and endocrine secretions, and cell proliferation (Ref.1). Somatostatin acts via a family of five GPCRs (G-Protein-Coupled Receptors) SSTR1-SSTR5 (Somatostatin Receptors) that are variably expressed throughout numerous tissues ranging from the CNS (Central Nervous System) to the Endocrine and Immune Systems. Somatostatin antiproliferative action results either from inhibition of trophic or growth factors secretion or from interference with the normal Cell Cycle Progression. Among the five Somatostatin receptors, SSTR2 (Somatostatin Receptor-2) plays a critical role in the negative control of normal and Tumor cell growth (Ref.2).

The mechanism involved in transmission of the antiproliferative effects of the SSTR2 has been attributed [...]


1.Down-regulation of pancreatic and duodenal homeobox-1 by somatostatin receptor subtype 5: a novel mechanism for inhibition of cellular proliferation and insulin secretion by somatostatin.
Zhou G, Sinnett-Smith J, Liu SH, Yu J, Wu J, Sanchez R, Pandol SJ, Abrol R, Nemunaitis J, Rozengurt E, Brunicardi FC.
Front Physiol. 2014 Jun 25;5:226. doi: 10.3389/fphys.2014.00226. eCollection 2014. Review.
2.Differential somatostatin receptor (SSTR) 1- expression and downstream effectors in histologic subtypesof growth hormone pituitary tumors.
Kiseljak-Vassiliades K, Xu M, Mills TS, Smith EE, Silveira LJ, Lillehei KO, Kerr JM, Kleinschmidt-DeMasters BK, Wierman ME.
Mol Cell Endocrinol. 2015 Dec 5;417:73-83. doi: 10.1016/j.mce.2015.09.016. Epub 2015 Sep 21.
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