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Apoptosis through Death Receptors

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Apoptosis is a cell suicide mechanism that enables metazoans to control cell number in tissues and to eliminate individual cells that threaten the animal s survival. Certain cells have unique sensors, termed DR (Death Receptors), on their surface, which detect the presence of extracellular death signals and, in response; they rapidly ignite the cell s intrinsic apoptosis machinery. Death Receptors belong to the TNF (Tumour Necrosis Factor) gene superfamily and generally can have several functions other than initiating apoptosis. Eight members of the Death Receptor family have been characterized so far: TNFR1 (Tumor Necrosis Factor Receptor-1) also known as DR1, CD120a, p55 and p60, Fas (also known as DR2, APO1 and CD95), DR3 (Death Receptor-3) (also known as APO-3, LARD, TRAMP and [...]


1.Fas death receptor signalling: roles of Bid and XIAP.
Kaufmann T, Strasser A, Jost PJ.
Cell Death Differ. 2012 Jan;19(1):42-50. doi: 10.1038/cdd.2011.121. Epub 2011 Sep 30.
2.Death receptor-ligand systems in cancer, cell death, and inflammation.
Walczak H.
Cold Spring Harb Perspect Biol. 2013 May 1;5(5):a008698. doi: 10.1101/cshperspect.a008698. Review.
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