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Assembly of RNA Polymerase-III Initiation Complex

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Description

The nuclei of all eukaryotic cells contain three different RNA Polymerases, designated I, II and III. Like the DNA Polymerase that catalyzes DNA replication, RNA Polymerases catalyze the formation of the phosphodiester bonds that link the nucleotides together to form a linear chain. Each eukaryotic RNA Polymerase catalyzes transcription of genes encoding different classes of RNA. Transcription by RNA Polymerase-III produces small, stable RNAs including tRNAs, the 5S rRNA associated with the large ribosomal subunit, one of the snRNA (small nuclear RNAs) required for pre-mRNA splicing, and the 7S RNA associated with the signal recognition particle involved in secretion of proteins and the insertion of membrane-spanning proteins into cellular membranes. The func┬Čtions of many other small RNAs produced by RNA [...]

References:

1.TFIIB-related factors in RNA polymerase I transcription.
Knutson BA, Hahn S.
Biochim Biophys Acta. 2013 Mar-Apr;1829(3-4):265-73. doi: 10.1016/j.bbagrm.2012.08.003. Epub 2012 Aug 30. Review.
2.Novel layers of RNA polymerase III control affecting tRNA gene transcription in eukaryotes.
Leśniewska E, Boguta M.
Open Biol. 2017 Feb;7(2). pii: 170001. doi: 10.1098/rsob.170001. Review.
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