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B-Cell Development

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B lymphoid cells are essential for the humoral immune response by producing a diverse range of antigen-specific antibodies. Antibody-mediated immunity is provided by two distinctive B cell lineages that diverge early in life. The better-known conventional, or B2, B cells provide adaptive immunity by producing high-affinity pathogen-specific antibodies, typically in a T cell-dependent manner. The pool of B2 cells is constantly replenished from hematopoietic stem and progenitor cells in the bone marrow [Ref.1]. B1a cells provide innate-like immunity by producing “natural” low-affinity, broad-specificity antibodies against a wide range of overlapping antigens, including self-antigens. In contrast to B2 cells, the pool of B1a cells is largely established at birth and these cells are able to self-renew as mature cells in the [...]


1.B lymphocytes: how they develop and function
LeBien TW, Tedder TF.
Blood. 2008 Sep 1; 112(5):1570-80. doi: 10.1182/blood-2008-02-078071. Review.
2.B-1 B cell development in the fetus and adult.
Montecino-Rodriguez E, Dorshkind K.
Immunity. 2012 Jan 27; 36(1):13-21. doi: 10.1016/j.immuni.2011.11.017. Review.
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