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BRCA1 Pathway

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BRCA1(Breast Cancer Susceptibility Protein-1) is a versatile protein that links DNA damage sensing and DDR effectors. BRCA1 interacts with tumour suppressors, DNA repair proteins and cell cycle regulators through its various functional domains and thereby has diverse roles in multiple DNA repair pathways (particularly HR, NHEJ and SSA (single-strand annealing)) and in checkpoint regulation. BRCA1 contains an amino-terminal RING domain that has E3 ubiquitin ligase activity (which catalyses protein ubiquitylation) and a BRCT(BRCA1 C-Terminal) domain that facilitates phospho-protein binding.BASC (BRCA1-Associated Genome Surveillance Complex), a super complex of BRCA1, is key to recognizing and repairing DNA damage. This complex includes tumor suppressors and DNA damage repair proteins MSH2, MSH6, MLH1, ATM (Ataxia-Telangiectasia), BLM (Bloom syndrome protein), and the RAD50-MRE11 (Meiotic Recombination-11)-NBS1 [...]


1.BRCA1 and BRCA2: different roles in a common pathway of genome protection.
Roy R, Chun J, Powell SN.
Nat Rev Cancer. 2011 Dec 23;12(1):68-78. doi: 10.1038/nrc3181. Review.
2.BRCA1, a 'complex' protein involved in the maintenance of genomic stability.
Savage KI, Harkin DP.
FEBS J. 2015 Feb;282(4):630-46. doi: 10.1111/febs.13150. Epub 2014 Dec 2. Review.
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