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BRCA1 Pathway

This image is a scaled-down version of the actual pathway image. It does not contain any links to the protein information pages.


The maintenance of genome integrity is essential to all life, but is particularly important to long-lived multicellular organisms, which are susceptible to cancer. DNA damage can take the form of base modifications, strand breaks, interstrand cross-links and other lesions. To deal with many types of damage, genomes have evolved multiple cellular defense mechanisms, including DNA repair and cell cycle checkpoint processes. Different pathways exist for specific kinds of DNA damage and the cell must have ways to decide which mechanism to use for a given lesion. These requirements imply that signaling networks not only sense the presence of DNA damage, but also receive specific input such as the chemical nature of the damage, the timing of the cell cycle, the [...]


1.FANCD2: a branch-point in DNA damage response?
Grompe M.
Nat Med. 2002 Jun;8(6): 555-6. No abstract available.
2.BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures.
Wang Y, Cortez D, Yazdi P, Neff N, Elledge SJ, Qin J.
Genes Dev. 2000 Apr 15;14(8):927-39.
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