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Biosynthesis of Tryptophan in Bacteria and Plants

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Tryptophan is an amino acid essential to survival. Amino acids serve as building blocks for proteins, as well as serving as starting points for the synthesis of vitamins and many other crucial cellular molecules. While most plants and microorganisms can produce all the amino acids they need, tryptophan is one of eight amino acids that cannot be produced by animals. Humans and animals do not themselves have the biosynthetic machinery to synthesize tryptophan but rely on dietary intake from bacteria and plants that do produce it.

Tryptophan is the least abundant of the essential amino acids. However, it is also one of the most crucial, as it is involved not only in protein synthesis, but also in the formulation of [...]


1.Protein architecture, dynamics and allostery in tryptophan synthase channeling.
Pan P, Woehl E, Dunn MF.
Trends Biochem Sci. 1997 Jan;22(1):22-7.
2.Tryptophan synthase: a multienzyme complex with an intramolecular tunnel.
Miles EW.
Chem Rec. 2001;1(2):140-51.
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