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Breast Cancer Regulation by Stathmin1

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Stmn1 (Stathmin-1) also referred to as Op18 (Oncoprotein-18) is a major regulator of microtubule dynamics. It is an evolutionarily well conserved 17 kDa cytoplasmic phosphoprotein that is highly expressed in a wide variety of cancers and its high abundance seems to be necessary for the maintenance of the transformed phenotypes. Breast cancers exhibit high levels of Stmn1 and may be resistant to anti-microtubule agents. Stmn1 destabilizes microtubule polymers of Alpha and Beta-Tubulin subunits, by promoting catastrophes that ultimately results in deregulation of cell cycle, hampering cell survival (Ref.1). One of the key properties of microtubules is that of ‘dynamic instability’. Dynamic instability comprises the continuous switching between catastrophes (depolymerization or shrinkage phase) and rescues (polymerization or growing phase) of individual [...]


1.Stathmin-dependent molecular targeting therapy for malignant tumor: the latest 5 years' discoveries and developments.
Biaoxue R, Xiguang C, Hua L, Shuanying Y.
J Transl Med. 2016 Sep 27;14(1):279. Review.
2.Stathmin regulates centrosomal nucleation of microtubules and tubulin dimer/polymer partitioning.
Ringhoff DN, Cassimeris L.
MolBiol Cell. 2009 Aug;20(15):3451-8. doi: 10.1091/mbc.E09-02-0140. Epub 2009 Jun 10.
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