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Description |
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Atherosclerosis, the pathological basis of CAD (Coronary Artery Disease) and Ischemic Stroke, is the commonest cause of death and disability in the western world. Atherosclerosis is a multifactorial, highly complex disease with numerous aetiologies simultaneously and sequentially collaborating in subtle ways to affect lesion development, progression and maturation to an advanced, disease-provoking entity (Ref.1). The lesion, or Atheroma, is an inflammatory site composed of a necrotic lipid-rich core, modified vascular endothelium, SMCs (Smooth Muscle Cells), foamy macrophages, lymphocytes and a variety of inflammatory mediators. Inflammation is the key event in Atherosclerotic Plaque fissuring and rupture, causing adverse clinical events. A variety of risk factors are known to be associated with the pathogenesis of Atherosclerosis. These include genetic and lifestyle factors [...] |
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References:
1. Chlamydia pneumoniae infection in atherosclerotic lesion development through oxidative stress: a brief overview.Di Pietro M, Filardo S, De Santis F, Sessa R.Int J Mol Sci. 2013 Jul 19;14(7):15105-20. doi: 10.3390/ijms140715105. Review.2. Infectious and coronary artery disease.Rezaee-Zavareh MS, Tohidi M, Sabouri A, Ramezani-Binabaj M, Sadeghi-Ghahrodi M, Einollahi B.ARYA Atheroscler. 2016 Jan;12(1):41-9. Review.
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