About Us
Contact Us
Login to Protein Lounge!

C. pneumoniae Infection in Atherosclerosis

This image is a scaled-down version of the actual pathway image. It does not contain any links to the protein information pages.


Atherosclerosis, the pathological basis of CAD (Coronary Artery Disease) and Ischemic Stroke, is the commonest cause of death and disability in the western world. Atherosclerosis is a multifactorial, highly complex disease with numerous aetiologies simultaneously and sequentially collaborating in subtle ways to affect lesion development, progression and maturation to an advanced, disease-provoking entity (Ref.1). The lesion, or Atheroma, is an inflammatory site composed of a necrotic lipid-rich core, modified vascular endothelium, SMCs (Smooth Muscle Cells), foamy macrophages, lymphocytes and a variety of inflammatory mediators. Inflammation is the key event in Atherosclerotic Plaque fissuring and rupture, causing adverse clinical events. A variety of risk factors are known to be associated with the pathogenesis of Atherosclerosis. These include genetic and lifestyle factors [...]


1.Chlamydia pneumoniae infection in atherosclerotic lesion development through oxidative stress: a brief overview.
Di Pietro M, Filardo S, De Santis F, Sessa R.
Int J Mol Sci. 2013 Jul 19;14(7):15105-20. doi: 10.3390/ijms140715105. Review.
2.Infectious and coronary artery disease.
Rezaee-Zavareh MS, Tohidi M, Sabouri A, Ramezani-Binabaj M, Sadeghi-Ghahrodi M, Einollahi B.
ARYA Atheroscler. 2016 Jan;12(1):41-9. Review.
You can get all the details on this pathway through subscription