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CCR3 Pathway in Eosinophils

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Human eosinophils are crucial effector cells implicated in a number of chronic inflammatory reactions, associated with bronchial asthma, allergic-inflammatory diseases, and parasitic infections.The chemotactic response of eosinophils is mostly mediated by CCR3 (CC Chemokine Receptor-3), a member of the G protein-coupled, seven-transmembrane receptor family, linked to heterotrimeric G-Proteins. Although its expression was first thought to be limited to eosinophils, CCR3 is now known to be more widely expressed on cells involved in allergic inflammation, such as basophils, macrophages, mast cells, neutrophils, airway epithelial cells, and potentially TH2 T-lymphocytes . Chemokines such as: Eotaxin, Eotaxin2, and Eotaxin3 signal exclusively via CCR3 that recruit eosinophils to the site of inflammation and activate them. On the other hand, the potent eosinophil-activating Beta-chemokines: [...]


1.Functional expression of CCL8 and its interaction with chemokine receptor CCR3.
Ge B, Li J, Wei Z, Sun T, Song Y, Khan NU.
BMC Immunol. 2017 Dec 28;18(1):54. doi: 10.1186/s12865-017-0237-5.
2.What can we learn from molecular dynamics simulations for GPCR drug design?
Tautermann CS, Seeliger D, Kriegl JM.
Comput Struct Biotechnol J. 2014 Dec 10;13:111-21. doi: 10.1016/j.csbj.2014.12.002. eCollection 2015.
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