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CDC42 Pathway

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Dynamic regulation of the actin cytoskeleton underpins a multitude of cellular processes, from cell movement and polarization1,2 to cell division.3 The actin cytoskeleton and the proteins involved in its regulation are also fundamentally linked to endocytosis and membrane trafficking.4,5 Members of the Rho family of small GTPases have emerged as important overseers of the actin cytoskeleton and a number of Rho family members and their downstream effector proteins have been linked to specific actin pathways. Among the Rho family actin regulators is Cdc42 is a small GTPase responsible for a large number of eukaryotic cell signaling pathways(Ref.1).

CDC42 acts downstream of cell surface receptors to regulate the formation of different F-actin-containing structures. It regulates actin polymerization to induce the assembly of [...]


1.Cdc42 in actin dynamics: An ordered pathway governed by complex equilibria and directional effector handover.
Watson JR, Owen D, Mott HR.
Small GTPases. 2017 Oct 2;8(4):237-244. doi: 10.1080/21541248.2016.1215657. Epub 2016 Aug 11. Review.
2.I'm coming to GEF you: Regulation of RhoGEFs during cell migration.
Goicoechea SM, Awadia S, Garcia-Mata R.
Cell Adh Migr. 2014;8(6):535-49. doi: 10.4161/cam.28721. Epub 2014 Oct 31. Review.
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