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CDC42 Pathway

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Dynamic rearrangements of the cytoskeleton and cell adhesion are required for various cellular processes, such as shape changes, migration, and cytokinesis. These temporal and spatial reorganizations of cell structure and cell contacts can be stimulated by extracellular signals, including Growth Factors, Hormones, Integrins, G-proteins and other biologically active substances. To achieve strong adhesion to their neighbors and sustain stress and tension, epithelial cells develop many different specialized adhesive structures. Breakdown of these structures occurs during tumor progression with the development of a fibroblastic morphology characteristic of metastatic cells. Adhesion receptors of the Cadherin family have been implicated in these cellular processes, which play an important role in the development and maintenance of the differentiated epithelial phenotype during organogenesis and adult [...]


1.Cdc42 is involved in PKCepsilon- and delta-induced neurite outgrowth and stress fibre dismantling.
Troller U, Larsson C.
Biochem Biophys Res Commun. 2006 Oct 13;349(1):91-8. Epub 2006 Aug 10.
2.The integrin alpha6beta1 modulation of PI3K and Cdc42 activities induces dynamic filopodium formation in human platelets.
Chang JC, Chang HH, Lin CT, Lo SJ.
J Biomed Sci. 2005 Dec;12(6):881-98. Epub 2005 Oct 14.
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