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CDK5 Pathway

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CDKs (Cyclin-dependent kinases) are a group of serine/threonine protein kinases activated by binding to a regulatory subunit cyclin.CDK5(Cyclin dependent kinase-5), a family member of the cyclin-dependent kinases, plays a pivotal role in the central nervous system. During embryogenesis, CDK5 is indispensable for brain development and, in the adult brain, it is essential for numerous neuronal processes, including higher cognitive functions such as learning and memory formation. However, CDK5 activity becomes deregulated in several neurological disorders, such as Alzheimer s disease, Parkinson s disease and Huntington s disease, which leads to neurotoxicity. Therefore, precise control over CDK5 activity is essential for its physiological functions. For its activation CDK5 also requires its specific binding partners CDK5R1 and CDK5R2 (hereafter referred to as p35 and p39, [...]


1.Cdk5 activity in the brain - multiple paths of regulation.
Shah K, Lahiri DK.
J Cell Sci. 2014 Jun 1;127(Pt 11):2391-400. doi: 10.1242/jcs.147553. Review.
2.Biological functions of CDK5 and potential CDK5 targeted clinical treatments.
Shupp A, Casimiro MC, Pestell RG.
Oncotarget. 2017 Mar 7;8(10):17373-17382. doi: 10.18632/oncotarget.14538. Review.
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