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CHKs in Checkpoint Regulation

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Description

The DNA damage response network involves several kinases to inactivate CDK/ cyclin complexes and result in cell cycle arrest for DNA repair. In the presence of DNA damage or incomplete DNA replication, eukaryotic cells activate cell cycle checkpoints that temporarily halt the cell cycle to permit DNA repair or completion of DNA replication to take place. In the presence of extensive damage or absence of timely repair, these checkpoint-signaling pathways may also trigger a pathway that effects programmed cell death or apoptosis. DNA damage-activated cell cycle checkpoints are regulated in part by the phosphoinositide kinase family of checkpoint components, including the yeast Rad3 in Schizosaccharomyces pombe, Mec1/Tel1 in Saccharomyces cerevisiae, mammalian ATM (Ataxia Telangiectasia-Mutated), ATR (ATM/Rad3-related), MEI-41 in Drosophila, and [...]

References:

1.Mitogen-activated protein kinase-activated protein kinase 2 in neuroinflammation, heat shock protein 27phosphorylation, and cell cycle: role and targeting.
Gurgis FM, Ziaziaris W, Munoz L.
Mol Pharmacol. 2014 Feb; 85(2):345-56. doi: 10.1124/mol.113.090365. Epub 2013 Dec 2. Review.
2.Chk1 and Chk2 kinases in checkpoint control and cancer.
Bartek J, Lukas J.
Cancer Cell. 2003 May; 3(5):421-9. Review.
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