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CNTF Signaling

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CNTF (Ciliary Neurotrophic Factor) is a protein expressed in glial cells, which stimulates gene expression and cell survival and differentiation in a variety of neuronal cell populations and acts as a lesion factor involved in the prevention of nerve degeneration after injury. It is a member of the IL6ST (130-kDa Glycoprotein) cytokine family along with structurally related hemato- and neuropoietic cytokines IL-6 (Interleukin-6), IL-11 (Interleukin-11), LIF (Leukemia Inhibitory Factor), OSM (OncoSOAT1in M), CT-1 (Cardiotrophin-1), Leptin and CLC (Cardiotrophin-Like Cytokine). The actions of CNTF are mediated, in part by CNTFR-Alpha (CNTF-specific Receptor). Upon translation, the C-terminus of CNTFR-Alpha is cleaved. Mature CNTFR-Alpha has no transmembrane or cytosolic domains and is found on the outer surface of the cell membrane where it [...]


1.The cytokine ciliary neurotrophic factor (CNTF) activates hypothalamic urocortin-expressing neurons both in vitro and in vivo.
Purser MJ, Dalvi PS, Wang ZC, Belsham DD.
PLoS One. 2013 Apr 23;8(4):e61616. doi: 10.1371/journal.pone.0061616. Print 2013.
2.CNTF and retina.
Wen R, Tao W, Li Y, Sieving PA.
Prog Retin Eye Res. 2012 Mar;31(2):136-51. doi: 10.1016/j.preteyeres.2011.11.005. Epub 2011 Dec 10. Review.
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