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Caspase Cascade

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Caspases are a family of evolutionary conserved cysteine dependent aspartate-specific proteases that play crucial roles in maintaining organismal homoeostasis throughout life.Mammalian caspases are broadly classified as being inflammatory/pyroptotic (human caspase-1, 4, 5 and 12, murine caspase-1, 11 and 12), or as initiators (human and murine caspase-2, 8, 9 and human caspase-10) and executioners (human and murine caspase-3, 6 and 7) of apoptotic cell death.The culmination of this cascade is the cleavage of a number of proteins in the cell, followed by cell disassembly, cell death, and, ultimately, the phagocytosis and removal of the cell debris. The Caspase cascade is activated by two distinct routes: one from cell surface and the other from mitochondria (Ref.1). The pathway leading to Caspase activation [...]


1.Caspases in metabolic disease and their therapeutic potential.
Wilson CH, Kumar S.
Cell Death Differ. 2018 Jun;25(6):1010-1024. doi: 10.1038/s41418-018-0111-x. Epub 2018 May 9.
2.Cellular mechanisms controlling caspase activation and function.
Parrish AB, Freel CD, Kornbluth S.
Cold Spring Harb Perspect Biol. 2013 Jun 1;5(6). pii: a008672. doi: 10.1101/cshperspect.a008672. Review.
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