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Cell Integrity Pathway In Budding Yeast

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Cellular integrity in the yeast Saccharomyces cerevisiae depends on the proper composition of the cell wall and is controlled by the PKC1 (Protein Kinase-C-1)-mediated signal transduction through a MAPK (Mitogen-Activated Protein Kinases) cascade. This pathway is generally activated by events that lead to a change of the cell s size or shape. The pathway is also important for processes such as cell fusion, polarized growth, regulation of actin cytoskeleton polarization, control of the morphogenesis checkpoint during cell cycle and several other events that affect cell membrane or cell wall composition. The cell integrity pathway orchestrates changes in cellular morphology by controlling the expression of genes encoding enzymes involved in cell wall metabolism, by directly controlling at least one such enzyme, and [...]


1.A family of genes required for maintenance of cell wall integrity and for the stress response in Saccharomyces cerevisiae.
Verna J, Lodder A, Lee K, Vagts A, Ballester R.
Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):13804-9.
2.Transcriptional coregulation by the cell integrity mitogen-activated protein kinase Slt2 and the cell cycle regulator Swi4.
Baetz K, Moffat J, Haynes J, Chang M, Andrews B.
Mol Cell Biol. 2001 Oct;21(19):6515-28.
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