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Cellular Transformation by HTLV1

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The HTLV-1(human T-lymphotropic virus type 1) is the etiological agent of ATL(adult T-cell leukemia). HTLV-1 Tax has been shown to have a prosurvival role in infected T cells by enhancing expression of the BCL-2 family of antiapoptotic proteins.After intensive studies, evidence has shown that the viral protein Tax has a key role in promoting viral spread and it is also one of the essential proteins involved in oncogenesis through multiple mechanisms, for example, promoting G1–S progression, enhancing the PI3K-AKT signaling pathway, inducing DNA hyper-replication, decreasing DNA repair, constitutive activation of NF-KappaB and suppression of apoptosis. Its ability to modulate the expression and function of many cellular genes is reasoned to be a major contributory mechanism explaining HTLV1 mediated transformation of [...]


1.Tax contributes apoptosis resistance to HTLV-1-infected T cells via suppression of Bid and Bim expression.
Mühleisen A, Giaisi M, Köhler R, Krammer PH, Li-Weber M.
Cell Death Dis. 2014 Dec 18;5:e1575. doi: 10.1038/cddis.2014.536.
2.HTLV-1 and apoptosis: role in cellular transformation and recent advances in therapeutic approaches.
Taylor JM, Nicot C.
Apoptosis. 2008 Jun;13(6):733-47. doi: 10.1007/s10495-008-0208-7. Review.
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