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Cla4-PAK Signaling in Budding Yeast

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Simple eukaryotes such as yeasts and molds encode multiple PAKs (p21-Activated Kinases) that, like their orthologs in other systems, act downstream of Rho-family GTPases to regulate cytoskeletal structure and gene transcription. All PAKs contain an N-terminal PBD (p21 GTPase-Binding-Domain), which confers binding to small GTPases such as CDC42 (Cell Division Cycle-42) or Rac, and a C-terminal protein kinase domain (Ref.1). Saccharomyces cerevisiae cells contain three members of this family, Ste20, Cla4, and Skm1, each of which performs a distinct set of cellular roles.

S. cerevisiae Cla4 contains a CDC42-binding domain, a PH (Pleckstrin Homology) domain, and a serine/threonine kinase domain and is required for viability in the absence of the G1 cyclins Cln1 and Cln2. Like Ste20, Cla4 is part of [...]


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