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Classical Complement Pathway

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Complement is a system of circulating enzymes that is part of the body s response to illness or injury. The complement system plays an essential role in host defence against infectious agents and in the inflammatory process. It consists of about thirty plasma proteins that function either as enzymes or as binding proteins. In addition to these plasma proteins, the complement system includes multiple distinct cell-surface receptors that exhibit specificity for the physiological fragments of complement proteins and that occur on inflammatory cells and cells of the immune system. There are also several regulatory membrane proteins that function to prevent autologous complement activation and protect host cells from accidental complement attack. The complement system can be activated by three different pathways: [...]


1.Complement: structure, functions, evolution, and viral molecular mimicry.
Mastellos D, Morikis D, Isaacs SN, Holland MC, Strey CW, Lambris JD.
Immunol Res. 2003;27(2-3):367-86.
2.C1q, autoimmunity and apoptosis.
Botto M, Walport MJ.
Immunobiology. 2002 Sep;205(4-5):395-406.
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