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Complement Pathway

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The C (Complement) system consists of about twenty plasma proteins that function either as enzymes or as binding proteins. In addition to these plasma proteins, the complement system includes multiple distinct cell-surface receptors that exhibit specificity for the physiological fragments of complement proteins and that occur on inflammatory cells and cells of the immune system. Activation of the complement system initiates a series of enzymatic reactions in which the proteolytic cleavage and activation of successive complement proteins leads to the covalent bonding or fixing of complement fragments to the pathogen surface. A major consequence of this is the uptake and destruction of complement coated microbes by phagocytes that bear receptors for these complement fragments (Ref.1).

Most complement proteins exist in [...]


1.Complement System Part II: Role in Immunity.
Merle NS, Noe R, Halbwachs-Mecarelli L, Fremeaux-Bacchi V, Roumenina LT.
Front Immunol. 2015 May 26;6:257. doi: 10.3389/fimmu.2015.00257. eCollection 2015. Review.
2.Complement System Part I - Molecular Mechanisms of Activation and Regulation.
Merle NS, Church SE, Fremeaux-Bacchi V, Roumenina LT.
Front Immunol. 2015 Jun 2;6:262. doi: 10.3389/fimmu.2015.00262. eCollection 2015. Review.
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