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DR3 Signaling

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Description

The TNFR (Tumor Necrosis Factor Receptor) superfamily comprises a growing family of type I membrane bound glycoproteins, which interact with the TNF family of soluble mediators and type II transmembrane proteins. At least 23 TNFR superfamily members and 17 known ligands have been identified in mammals. These receptors trigger pleiotropic responses, ranging from apoptosis and differentiation to proliferation, and have been implicated in immune regulation, host defense and lymphoid organ development. Members of the TNFR family are characterized by the presence of varying numbers (two to six) of cysteine-rich repeats in their cytoplasmic domains. Among these molecules, a novel subgroup has been defined, termed DR (Death Receptors), as one of their most prominent functions is to induce apoptosis. DR are [...]

References:

1.Membrane trafficking of death receptors: implications on signalling.
Schneider-Brachert W, Heigl U, Ehrenschwender M.
Int J Mol Sci. 2013 Jul 11;14(7):14475-503. doi: 10.3390/ijms140714475. Review.
2.The death receptor 3/TL1A pathway is essential for efficient development of antiviral CD4? and CD8? T- cell immunity.
Twohig JP, Marsden M, Cuff SM, Ferdinand JR, Gallimore AM, Perks WV, Al-Shamkhani A, Humphreys IR, Wang EC.
FASEB J. 2012 Aug;26(8):3575-86. doi: 10.1096/fj.11-200618. Epub 2012 May 16.
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