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DREAM Repression and Dynorphin Expression

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Description

The experience of pain in response to noxious stimuli serves a crucial biological purpose: it alerts a living organism to environmental dangers, inducing behavioral responses that protect the organism from further damage. In contrast, chronic pain arising from disease states and/or pathological functioning of the nervous system offers no advantage and may be debilitating to those afflicted. Control and treatment of chronic pain remain major clinical challenges. The calcium-sensing protein DREAM (Downstream Regulatory Element Antagonistic Modulator) is a putative transcriptional repressor involved in modulating pain (Ref.1).

DREAM is constitutively expressed in certain neurons and transcriptional activity of the repressor DREAM depends on its high affinity binding to a DRE (Downstream Response Element) site in target genes, which is important in regulating [...]

References:

1.The potassium channel interacting protein 3 (DREAM/KChIP3) heterodimerizes with and regulates calmodulin function.
Ramachandran PL, Craig TA, Atanasova EA, Cui G, Owen BA, Bergen HR 3rd, Mer G, Kumar R.
J Biol Chem. 2012 Nov 16;287(47):39439-48. doi: 10.1074/jbc.M112.398495. Epub 2012 Sep 27.
2.DREAM plays an important role in platelet activation and thrombogenesis.
Kim K, Tseng A, Barazia A, Italiano JE, Cho J.
Blood. 2017 Jan 12;129(2):209-225. doi: 10.1182/blood-2016-07-724419. Epub 2016 Nov 30.
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