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Developmental Cycle of C. pneumoniae

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The Chlamydiae are Gram-negative bacteria that are obligate intracellular parasites of eukaryotic cells and are the etiologic agents of several human diseases. These parasites depend on their host cell for growth and prolonged survival (Ref.1). Chlamydia pneumoniae is a common human pathogen and can lead to upper respiratory tract infections, including Pharyngitis, Bronchitis, Sinusitis, Community Acquired Pneumonia, Otitis Media, and is currently of intense interest due to its associations with atherosclerosis and other chronic diseases (Ref.2). Humans encounter C. pneumoniae commonly with most individuals having several infections during their lifetime. C. pneumoniae exhibits the capacity to infect and multiply within a wide range of host cells, including Monocytes, Macrophages and Endothelial cells. The organism’s unique biphasic life cycle alternates between [...]


1.Chlamydia pneumoniae--an infectious risk factor for atherosclerosis?
Campbell LA, Kuo CC.
Nat Rev Microbiol. 2004 Jan;2(1):23-32.
2.The chlamydial inclusion: escape from the endocytic pathway.
Fields KA, Hackstadt T.
Annu Rev Cell Dev Biol. 2002;18:221-45. Epub 2002 Apr 02.
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