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ENOS Signaling

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NO (Nitric Oxide) is a short-lived free radical gas involved in diverse physiological and pathological processes. It is produced along with L-Citrulline by the oxidation of L-Arginine and catalyzed by three different isoforms of NOS (NO Synthase). Type-I nNOS (neuronal NOS) and Type-III eNOS (endothelial NOS) are constitutively expressed as latent enzymes and require a higher concentration of Ca2+ for the enzyme activity. In contrast, Type-II iNOS (inducible NOS) is Ca2+ independent because it’s high affinity for Ca2+/Calm (Calmodulin) renders the enzyme active even at basal levels of intracellular Ca2+ . The catalysis of this reaction requires a number of essential cofactors such as mononucleotide, FAD (Flavin Adenine Dinucleotide), and NADPH (Nicotinamide Adenine Dinucleotide, Reduced). The NO thus generated exerts [...]


1.Neuronal Nitric Oxide Synthase in Vascular Physiology and Diseases.
Costa ED, Rezende BA, Cortes SF, Lemos VS.
Front Physiol. 2016 Jun 2;7:206. doi: 10.3389/fphys.2016.00206. eCollection 2016. Review.
2.Molecular mechanisms of endothelial NO synthase uncoupling.
Luo S, Lei H, Qin H, Xia Y.
Curr Pharm Des. 2014;20(22):3548-53. Review.
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