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ER-Mediated Phagocytosis

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Phagocytosis, defined as the cellular uptake of particulates (>0.5 m) within a plasma-membrane envelope, is closely related to and partly overlaps the endocytosis of soluble ligands by fluid-phase macropinocytic and receptor pathways. The uptake of exogenous particles (heterophagy) has features in common with autophagy, an endogenous process of sequestration and lysosomal disposal of damaged intracellular organelles. There is a spectrum of uptake mechanisms depending on the particle size, multiplicity of receptor-ligand interactions, and involvement of the cytoskeleton. Once internalized, the phagosome vacuole can fuse selectively with primary lysosomes or the product of the endoplasmic reticulum (ER) and Golgi complex, to form a secondary phagolysosome. This pathway is dynamic in that it undergoes fusion and fission with endocytic and secretory vesicles [...]


1.Phagocytosis: An Immunobiologic Process.
Gordon S.
Immunity. 2016 Mar 15; 44(3):463-475. doi: 10.1016/j.immuni.2016.02.026. Review.
2.Phagocytosis: A Fundamental Process in Immunity.
Rosales C, Uribe-Querol E.
Biomed Res Int. 2017; 2017:9042851. doi: 10.1155/2017/9042851. Epub 2017 Jun 12. Review.
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