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Endocytic Trafficking of EGFR

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Description

All cells need to interpret their environment. Efficient processing of signals from the extracellular milieu is achieved through dynamic signal-transduction systems. The components of this system that come into contact first with external signals are cell-surface receptors. RTKs (Receptor Tyrosine Kinases) comprise one large group of receptors that respond to polypeptide growth factors and have intrinsic tyrosine kinase activity. On ligand binding, receptor signaling is activated. The activation of RTKs initiates signal transduction and receptor endocytosis. Most activated RTKs are efficiently cleared from the cell surface by endocytosis and sorted to Lysosomes for degradation. In contrast, inactive RTKs are constitutively internalized and recycled back to the cell surface, an essential mechanism for the restoration of unused receptors. Simultaneous signal transduction [...]

References:

1.The EGFR odyssey - from activation to destruction in space and time.
Bakker J, Spits M, Neefjes J, Berlin I.
J Cell Sci. 2017 Dec 15;130(24):4087-4096. doi: 10.1242/jcs.209197. Epub 2017 Nov 27. Review.
2.Measurement of Epidermal Growth Factor Receptor-Derived Signals Within Plasma Membrane Clathrin Structures.
Lucarelli S, Delos Santos RC, Antonescu CN.
Methods Mol Biol. 2017;1652:191-225. doi: 10.1007/978-1-4939-7219-7_15.
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